The Laboratory work is dedicated to one of the most relevant and dynamic developing fields of Biology – comparative study of the genome and chromosomes, and of crucial genes for organization and development.

 Research in different fields of genomics is carried out at the Laboratory:

  •  Sructural and functional organization of chromosomes, and clustered organization of genes;
  •  Molecular organization of heterochromatin in animals and plants;
  •  Development of a system aimed at introducing targeted modifications in the genome;
  •  Organization and evolution of vertebrate genomes and chromosomes; 
  •  Paleogenomics;
  •  Structure of extra chromosomes;
  •  Chromosomal systems in sex-determination;
  •  Functional and evolutionary analysis of the genomic components of the immune system.

 

Collaborators of our Laboratory take part in several large-scale international projects, such as modENCODE, Genome 10k and others. Within the framework of the international project in sequencing genomes of 10 thousands species of vertebrates (Genome 10K), a comparative study of the genomes of 48 species of birds, belonging to the main taxa of this class, was conducted. Phylogenetic relationships among taxa were established, and it was proved that many adaptations, for instance for aquatic life or singing, occurred repeatedly throughout evolution of birds. Characteristics of the organization of the genomes of birds, which essentially differentiate them from other classes of vertebrates, are determined.

 The Laboratory was created at the Department of Natural Sciences of NSU and conducts research together with the Institute of Molecular and Cellular Biology of the Siberian Branch of the Russian Academy of Sciences (SB RAS.)

 The Laboratory carries out studies together with foreign Research centers:

  •   Analysis of the centromeric heterochromatin of Drosophila – University of California, Berkeley (USA); Institute of Genetics of the University of Halle-Wittenberg (Germany); Department of Genetics and molecular Biology, University of Rome (Italy); Center for Molecular Biology, Autonomous University of Madrid (Spain);
  •  Microarray data analysis of Gene expression – department of Molecular Biology, Cancer Institute, Amsterdam (the Netherlands);
  •  Study about the dosage compensation system of Drosophila, Department of Genetics, Harvard University, Boston (USA);
  •  Research on karyotypic evolution and sex chromosomes in reptiles – Cambridge Resource Centre for Comparative Genomics, Cambridge University (GB);
  •  Comparative Genomics – Frederick National Laboratory for Cancer Research (USA); Cornell University, Ithaca (USA); The University of North Carolina at Chapel Hill (USA); Institute of Human Genetics, Jena (Germany); National Museum of Natural History in Paris (France); University of Florence (Italy); Kunming Institute of Zoology (China);
  •  Cytogenetic analysis in the neotropical fish – University of Sao Paulo, Rio Carlo Campus, São Paulo (Brazil.)

   

Experts in this field – Doctor in Biological Sciences, Professor, Academician, Igor F. Zhimulev, zhimulev@mcb.nsc.ru

Institute of Molecular and Cellular Biology of the Siberian Branch of the Russian Academy of Sciences