The main area of the laboratory research is the study of the organic compounds structure and the mechanisms of chemical reactions involving radicals, radical ions, carbo-cations applying the methods of magnetic resonance, X-ray spectroscopy, nuclear magnetic resonance spectroscopy, electron paramagnetic resonance (EPR) and EPR imaging, infrared spectroscopy . Objects of the research are new functional nano-structured materials, molecular magnets (including thermal / light-switchable), and porous metal-organic polymers of different types that are promising for applications in spintronics and nanotechnology, as well as newly synthesized organic compounds.
Another area of research is the use of EPR spectroscopy to solve important biological problems, in obtaining information about the structure of protein complexes and nucleic acids in liquids on the nanometer scale applying the method of spin probes using trityl and nitroxides radicals synthesized at the Institute of Organic Chemistry SB RAS. New approaches and unique combinatory techniques for the study of nanomaterials and biopolymers have been developed.
The results of the laboratory functioning are the following:
- The plant for the perfusion of rat hearts has been developed to carry out retrograde perfusion and to observe contractile function in isolated rat hearts placed directly in the cavity of the EPR spectrometer. Measurements of oxygen and pH concentration of the myocardial tissue have been accomplished using EPR on the perfused rat heart;
- The molecular structure of a number of biologically active compounds, novel derivates of nitroxides radicals, promising organic materials with different conductive and optical properties has been identified; electrochemistry C (sp2) -linked Nitron-nitroxyl biradicals has been investigated, the electrochemical desoxidation and oxidation of a number of Nitron-nitroxyl radicals;
- The properties of new thermal and light-switching molecular nanomagnets based on copper complexes with nitroxyl radicals have been studied. The mechanism of light-induced switching of spin states in these systems as well as the critical factors that determine the stability of the light-induced state have been determined;
- EPR and IR spectroscopy methods have been used to study a series of porous metal-polymer whose structure is switchable under the influence of temperature and / or sorption / desorption of guest molecules; The mechanism of recombination reactions and disproportioning of nitroxyl radicals with alkyl (modeling acrylate and styrene monomer radicals) and oxy-centered radicals (hydroxyl, superoxide, etc.) has been studied. The factors affecting constants of recombination rates (steric hindrance, polarity, stabilization).
Partners Laboratories: International tomographic Center, Siberian Branch of the Russian Academy of Sciences,
University of Provence (Marseille, France),
Tohoku University (Japan), Univeristy of Mülheim (Germany).
Head of the Laboratory: Doctor in Physics and Mathematics Elena Bagryanskaya,
egbagryanskaya@nioch.nsc.ru
Division of Organic Chemistry Department of Natural Sciences at NSU
Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences 