The main directions of the laboratory activity:

1. Modeling repair enzymes activity at the molecular level.

Repair enzymes eliminate damage to the cell DNA, and the study of their activity has both fundamental and applied importance: blocking the activity of some enzymes helps to kill cancer cells.

2. Designing protein structures to invoke an immune response against HIV.

Despite years of efforts of many scientists, an effective vaccine against HIV has not yet been created. At the same time, some HIV infected patents have antibodies that very efficiently neutralize the virus. The study of the mechanism of such antibodies formation is of fundamental and practical interest.

3. Simulation of the amyloid fibrils formation in various conditions.

Alzheimer's disease is a serious health problem and there is still no effective treatment for it. It is accompanied by the formation of specific protein aggregates, i. e. amyloid fibrils. Fighting their formation may be one of the promising areas of therapy, and for this it is necessary to study their structural and dynamic properties, including molecular modeling methods.

The international partner of the laboratory: National Center for Scientific Research of France.

Head of the laboratory – PhD in Biology Anastasia Bakulina, bakulina@gmail.com

Division of Molecular Biology Department of Natural Sciences NSU
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences